一个简单的规则决定了人类牙的大小的演变和发展
Alistair R Evans1,2, E Susanne Daly3,4, Kierstin K Catlett3,4
1School of Biological Sciences, Monash University, Victoria 3800, Australia.
Nature
|February 26, 2016
概括
抑制级联机制控制了人类的牙大小演变,解释了和前发育的模式. 这种发育规则预测人类祖先和现代人类的牙大小.
科学领域:
- 进化生物学
- 发育生物学
- 古牙科
背景情况:
- 人类牙大小的变化对人类进化产生了重大影响.
- 之前的假设将牙大小的减少归因于饮食变化或,但潜在的发育控制仍然不清楚.
研究的目的:
- 调查人类牙大小演变的规则.
- 确定导致观察到的牙大小变化的发育机制.
主要方法:
- 作为哺乳动物相对牙大小的驱动器,提出了抑制级联,一种激活器-抑制器机制.
- 分析了包括现代人类在内的南动物和人种的牙大小模式.
主要成果:
- 抑制级联解释了原始狗后牙大小的默认模式,相当于形态遗传梯度.
- 在Homo物种中,牙的比例和绝对大小紧密相关,可以通过单一的发育参数来解释.
- 一个位置上的牙大小可以预测人类其他四个主要的后犬牙的大小.
结论:
- 抑制级联为人类牙产生形态遗传梯度提供了一个发育机制.
- 这种框架为研究人类独特牙比例的演变提供了基于发展的预期.
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