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相关概念视频

Reduction of Alkynes to cis-Alkenes: Catalytic Hydrogenation02:24

Reduction of Alkynes to cis-Alkenes: Catalytic Hydrogenation

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Introduction
Like alkenes, alkynes can be reduced to alkanes in the presence of transition metal catalysts such as Pt, Pd, or Ni. The reaction involves two sequential syn additions of hydrogen via a cis-alkene intermediate.
9.4K
Reduction of Alkenes: Catalytic Hydrogenation02:13

Reduction of Alkenes: Catalytic Hydrogenation

14.8K
Alkenes undergo reduction by the addition of molecular hydrogen to give alkanes. Because the process generally occurs in the presence of a transition-metal catalyst, the reaction is called catalytic hydrogenation.
Metals like palladium, platinum, and nickel are commonly used in their solid forms — fine powder on an inert surface. As these catalysts remain insoluble in the reaction mixture, they are referred to as heterogeneous catalysts.
The hydrogenation process takes place on the...
14.8K
Reduction of Alkenes: Asymmetric Catalytic Hydrogenation02:17

Reduction of Alkenes: Asymmetric Catalytic Hydrogenation

4.0K
Catalytic hydrogenation of alkenes is a transition-metal catalyzed reduction of the double bond using molecular hydrogen to give alkanes. The mode of hydrogen addition follows syn stereochemistry.
The metal catalyst used can be either heterogeneous or homogeneous. When hydrogenation of an alkene generates a chiral center, a pair of enantiomeric products is expected to form. However, an enantiomeric excess of one of the products can be facilitated using an enantioselective reaction or an...
4.0K
Aldehydes and Ketones with HCN: Cyanohydrin Formation Overview01:32

Aldehydes and Ketones with HCN: Cyanohydrin Formation Overview

4.3K
Cyanohydrins are compounds that contain –CN and –OH groups on the same carbon atom. They are formed by the nucleophilic addition of the cyanide ions to the carbonyl group. Cyanide ions are highly basic and nucleophilic and can be generated from HCN under aqueous conditions. However, since HCN is a weak acid, the number of cyanide ions generated is very small. Hence, a small amount of base or KCN/NaCN is added to HCN to increase the concentration of the cyanide ions in the reaction...
4.3K
Alkynes to Aldehydes and Ketones: Hydroboration-Oxidation02:47

Alkynes to Aldehydes and Ketones: Hydroboration-Oxidation

21.8K
Introduction
One of the convenient methods for the preparation of aldehydes and ketones is via hydration of alkynes. Hydroboration-oxidation of alkynes is an indirect hydration reaction in which an alkyne is treated with borane followed by oxidation with alkaline peroxide to form an enol that rapidly converts into an aldehyde or a ketone. Terminal alkynes form aldehydes, whereas internal alkynes give ketones as the final product.
21.8K
Aldehydes and Ketones with HCN: Cyanohydrin Formation Mechanism01:10

Aldehydes and Ketones with HCN: Cyanohydrin Formation Mechanism

4.7K
Cyanohydrins are formed when cyanide nucleophiles and carbonyl compounds like aldehydes and ketones react. A strong base, the cyanide ion, catalyzes cyanohydrin formation. The ions are generated from HCN under aqueous conditions. Once the cyanide ions are generated, the first step involves the nucleophilic attack of the cyanide ions on the electrophilic carbonyl carbon. This attack shifts the π electrons from the C=O to the oxygen atom forming the alkoxide ion intermediate. The alkoxide anion...
4.7K

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Synthesis of Hypervalent Iodonium Alkynyl Triflates for the Application of Generating Cyanocarbenes
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Synthesis of Hypervalent Iodonium Alkynyl Triflates for the Application of Generating Cyanocarbenes

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通过可控转移化催化可逆基-基互转

Xianjie Fang1, Peng Yu1, Bill Morandi2

  • 1Max-Planck-Institut für Kohlenforschung, Mülheim an der Ruhr, Nordrhein-Westfalen 45470, Germany.

Science (New York, N.Y.)
|February 26, 2016
PubMed
概括

研究人员开发了一种催化反应,用于使用烯的更安全的化. 这种方法避免了有毒的化 (HCN),为有价值的化学物质提供了新的合成途径.

科学领域:

  • 有机化学
  • 催化剂
  • 合成方法

背景情况:

  • 和是合成材料,制药和农业化学品的关键组成部分.
  • 传统的化方法通常依赖于有毒的化 (HCN),造成重大安全风险.
  • 开发更安全,更通用的合成途径对于现代化学研究至关重要.

研究的目的:

  • 报告一种新的催化转移化反应.
  • 为传统的基于HCN的化方法提供更安全的替代方案.
  • 探索新的合成可能性,包括逆化和抗马尔科夫尼科夫区域选择性.

主要方法:

  • 使用催化剂调节转移化反应.
  • 使用广泛的基和基 (60个例子) 来证明基板范围.
  • 研究了可逆性基水功能化的热力学控制的转移反应.

主要成果:

  • 成功地证明了各种和的化转移化.
  • 在化过程中实现了反马尔科夫尼科夫区域选择性.
  • 展示了可逆水功能化的潜力, 规避危险的试剂.

结论:

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  • 开发的催化转移化为传统方法提供了更安全,更有效的替代方案.
  • 这种策略扩大了和在有机合成中的合成效用.
  • 这项工作在开发可持续和可控的水功能化反应方面取得了重大进展.