普鲁士蓝色纳米颗粒作为多酶模拟剂和反应性氧物种清除剂
Wei Zhang1, Sunling Hu1, Jun-Jie Yin2
1State Key Laboratory of Bioelectronics, Jiangsu Key Laboratory for Biomaterials and Devices, School of Biological Science and Medical Engineering & Collaborative Innovation Center of Suzhou Nano Science and Technology, Southeast University , Nanjing 210096, P. R. China.
Journal of the American Chemical Society
|February 27, 2016
概括
普鲁士蓝色纳米粒子 (PBNPs) 表现出类似多酶的活性,有效地清除反应性氧物种 (ROS). 这些纳米颗粒显示出在各种病理条件下预防ROS诱导的损伤的潜力.
科学领域:
- 纳米技术
- 生物化学
- 材料科学
背景情况:
- 反应性氧物种 (ROS) 与纳米材料毒性有关.
- 了解ROS清理机制对于开发更安全的纳米材料至关重要.
研究的目的:
- 调查普鲁士蓝色纳米粒子 (PBNPs) 的ROS清理能力.
- 阐明 PBNP 的 ROS 调节的基本机制.
- 评估PBNPs在ROS相关病理中的治疗潜力.
主要方法:
- 使用化学剂,紫外线照射,氧化低密度脂蛋白,高葡萄糖和氧-葡萄糖剥夺/再输液建立了体外ROS生成模型.
- 在体内研究中使用了癌症研究所 (ICR) 小鼠的炎症模型.
- 评估了PBNPs的类似酶的活性 (过氧化酶,氧化酶,超氧化酶).
主要成果:
- 通过过氧化酶 (POD) 模仿行为,PBNPs表现出显著的ROS清除活性,抑制基生成.
- 多酶类活动归因于PBNP的氧化还原潜力,促进电子运输.
- 在体外和体外模型中,PBNP有效抑制或缓解ROS引起的损伤.
结论:
- 通过多酶类活动,PBNP具有强大的ROS清除特性.
- PBNPs作为POD模仿剂,防止有害的基形成.
- 在各种病理情况下,PBNPs有望减轻ROS引起的损害.
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