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Extraction and Visualization of Protein Aggregates after Treatment of Escherichia coli with a Proteotoxic Stressor
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RQC 机器的故障导致蛋白质聚合和蛋白质毒性应激

Young-Jun Choe1, Sae-Hun Park1, Timm Hassemer1

  • 1Department of Cellular Biochemistry, Max Planck Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany.

Nature
|March 3, 2016
PubMed
概括

由于缺少止子导致核糖体停滞导致蛋白质聚合和神经退行. 核糖体质量控制 (RQC) 机制通常可以防止这种情况发生,但其故障会破坏蛋白质平衡.

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