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相关概念视频

Viral Structure00:56

Viral Structure

75.7K
Viruses are extraordinarily diverse in shape and size, but they all have several structural features in common. All viruses have a core that contains a DNA- or RNA-based genome. The core is surrounded by a protective coat of proteins called the capsid. The capsid is composed of subunits called capsomeres. The capsid and genome-containing core are together known as the nucleocapsid.
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Antibody Structure01:10

Antibody Structure

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Overview
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...
67.3K
Antibody Structure01:10

Antibody Structure

15.1K
15.1K
Size and Structure of Viral Genomes01:26

Size and Structure of Viral Genomes

1.0K
Viral genomes exhibit remarkable diversity in size, structure, and composition, influencing their replication strategies and interactions with host cells. These genomes consist of either DNA or RNA and may be linear or circular. Additionally, they can be single-stranded or double-stranded, with each configuration affecting how the virus propagates within a host. RNA viruses, for instance, generally have smaller genomes than DNA viruses, a factor that contributes to their high mutation rates and...
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ATP Synthase: Structure01:18

ATP Synthase: Structure

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ATP synthase or ATPase is among the most conserved proteins found in bacteria, mammals, and plants. This enzyme can catalyze a forward reaction in response to the electrochemical gradient, producing ATP from ADP and inorganic phosphate. ATP synthase can also work in a reverse direction by hydrolyzing ATP and generating an electrochemical gradient. Different forms of ATP synthases have evolved special features to meet the specific demands of the cell. Based on their specific feature, ATP...
17.2K
Nucleic Acid Structure01:25

Nucleic Acid Structure

10.1K
The pentose sugar in DNA is deoxyribose, while in RNA the pentose sugar is ribose. The difference between the sugars is the presence of the hydroxyl group on the ribose's second carbon and a hydrogen on the deoxyribose's second carbon. The phosphate residue attaches to the hydroxyl group of the 5′ carbon of one sugar and the hydroxyl group of the 3′ carbon of the sugar of the next nucleotide, which forms  a 5′ to 3′ phosphodiester linkage.
DNA Structure
DNA...
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Production of Pseudotyped Particles to Study Highly Pathogenic Coronaviruses in a Biosafety Level 2 Setting
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人类冠状病毒尖端蛋白的融合前结构

Robert N Kirchdoerfer1, Christopher A Cottrell1, Nianshuang Wang2

  • 1Department of Integrative Structural and Computational Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.

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|March 4, 2016
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概括

研究人员确定了HKU1冠状病毒尖端蛋白的结构,揭示了它如何结合细胞和融合膜. 这一发现有助于开发针对人类β冠状病毒的干预措施和疫苗.

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科学领域:

  • 结构生物学
  • 病毒学
  • 分子生物学

背景情况:

  • 人类β型冠状病毒HKU1引起普遍的呼吸系统疾病.
  • 像SARS和MERS这样的冠状病毒构成流行病威胁.
  • 尖峰 (S) 蛋白决定细胞的热带性和宿主范围.

研究的目的:

  • 确定HKU1冠状病毒S蛋白的结构.
  • 了解病毒进入和膜融合的分子机制.
  • 为设计β冠状病毒疫苗提供基础.

主要方法:

  • 单粒子冷电子显微镜 (冷EM).
  • 确定了三元蛋白HKU1S的4.0 Å分辨率结构.

主要成果:

  • 融合前的结构显示了S1子单位在S2子单位之上,抑制了构造变化.
  • 跨位的S1C终端域形成四级相互作用,阻断已知的受体结合表面.
  • 它的结构揭示了病毒进入的关键蛋白酶位点.

结论:

  • 这些发现支持通过受体结合和蛋白解驱动的S蛋白不稳定化的膜融合模型.
  • 该结构是针对β冠状病毒的基于结构的疫苗设计的基础.