酒精和心血管事件的直接风险:系统性审查和剂量反应元分析
Elizabeth Mostofsky1, Harpreet S Chahal2, Kenneth J Mukamal2
1From Cardiovascular Epidemiology Research Unit, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA (E.M., H.S.C., M.A.M.); Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA (E.M., E.B.R., M.A.M.); Department of Epidemiology and Biostatistics, Schulich School of Medicine & Dentistry, Western University, London, ON, Canada (H.S.C.); Division of General Medicine and Primary Care, Beth Israel Deaconess Medical Center, Boston, MA (K.J.M.); Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA (E.B.R.); and Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA (E.B.R.). emostofs@mail.harvard.edu.
任何饮酒都会增加心血管疾病的风险. 在接下来的几天里,大量饮酒会增加风险,而适度饮酒可能会在24小时后提供保护.
科学领域:
- 心脏病学
- 公共卫生
- 流行病学
背景情况:
- 关于与饮酒相关的直接心血管风险的数据有限.
- 酒精的生理影响可能会对短期和长期心血管风险产生差异性影响.
研究的目的:
- 描述酒精摄入后的直接心血管风险.
- 评估饮酒模式与饮酒后数小时和数天内心血管事件之间的关联.
主要方法:
- 观察性研究的系统审查和元分析.
- 在CINAHL,PubMed数据库中进行了搜索.
- 结合了心肌梗塞,缺血性中风和出血性中风的相对风险和置信区间.
主要成果:
- 任何酒精消耗都与心血管风险的立即增加有关.
- 在24小时后,适度摄入 (2-4杯) 显示肌肉心脏病发作和出血性中风的风险降低.
- 在24小时至一周内,大量饮酒 (6-9杯) 会显著增加心血管风险.
结论:
- 任何饮酒都会增加心血管疾病的风险.
- 严重的酒精摄入造成超过24小时的持续心血管风险.
- 在最初的几个小时后,适度饮酒可能会对心血管产生保护作用.
相关概念视频
CNS Depressants: Alcohol and Nicotine
Exercise and Cardiovascular Response
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
Cardiovascular Drugs: Classification based on Therapeutic Indications
Drug Toxicity: Risk factors
Effect of Hepatic Disease on Pharmacokinetics: Dose Adjustments Due to Hepatic Impairment
Hypothesis Test for Test of Independence
H0: The two variables (factors)...


