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克隆新抗原引起T细胞免疫反应和对免疫检查点阻塞的敏感性

Nicholas McGranahan1, Andrew J S Furness2, Rachel Rosenthal3

  • 1The Francis Crick Institute, London WC2A 3LY, UK. Centre for Mathematics and Physics in the Life Sciences and Experimental Biology (CoMPLEX), University College London (UCL), London WC1E 6BT, UK. Cancer Research UK Lung Cancer Centre of Excellence, UCL Cancer Institute, London WC1E 6BT, UK.

Science (New York, N.Y.)
|March 5, 2016
PubMed
概括

瘤新抗原异质性会影响免疫反应. 针对克隆新抗原可以提高免疫检查点抑制剂在肺癌和黑色素瘤的疗效.

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