通过三黄金催化剂对基因和序列性1,6-基因循环聚合物添加分子间同基醇
Seyedmorteza Hosseyni1, Lukasz Wojtas1, Minyong Li2
1Department of Chemistry, University of South Florida , Tampa, Florida 33620, United States.
Journal of the American Chemical Society
|March 10, 2016
概括
一种新型的三黄金催化剂促进了分子间的基添加和独特的1,6-基环化,产生了二素. 随后的反应产生了具有高立体选择性的酸,在一个步骤中产生了五个立体中心.
科学领域:
- 有机化学
- 催化剂
- 合成方法
背景情况:
- 确定了同质醇的黄金催化循环.
- 终端基因可以阻碍分子内循环.
研究的目的:
- 探索一种新型的三黄金催化剂,
- 开发复杂有机分子的新合成途径.
主要方法:
- 使用三醇黄金催化剂进行同质醇转化.
- 研究了一种序列式的1,6-烯循环聚合.
- 进行了迪尔斯-阿尔德反应和1,3-基转移.
主要成果:
- 实现分子间添加到基,防止分子内循环.
- 通过1,6-enyne循环相聚化合成不寻常的2,3-二素.
- 通过一种新的反应级联获得高产量的酸衍生物.
- 证明了五个立体中心的二分立体选择性形成,具有出色的反选择性.
结论:
- 三黄金催化剂可以实现独特的分子间添加和循环异构.
- 从同质醇制成酸的新合成途径.
- 这种方法可以有效地构建复杂的立体中心.
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