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与自闭症相关的SHANK3哈普洛因不足会导致人类神经元的Ih通道病变

Fei Yi1, Tamas Danko2, Salome Calado Botelho1

  • 1Department of Molecular and Cellular Physiology, Stanford University School of Medicine, 265 Campus Drive, Stanford, CA 94305, USA.

Science (New York, N.Y.)
|March 12, 2016
PubMed
概括

SHANK3突变会损害高极化激活的阳离子 (Ih) 通道,导致与自闭症相关的神经元和突触变化. 这表明自闭症谱系障碍的潜在治疗目标.

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