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iChip

iChip

The cultivation of environmental microorganisms has long been hindered by the inability to replicate complex native conditions in vitro. The isolation chip (iChip) addresses this limitation by facilitating the growth of previously uncultivable microorganisms through in situ incubation. Designed for high-throughput microbial cultivation, the iChip comprises hundreds of microchambers, each capable of housing a single microbial cell. These microchambers are loaded with a mixture of molten agar and...

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Updated: May 1, 2026

Scalable Fabrication of Stretchable, Dual Channel, Microfluidic Organ Chips

Scalable Fabrication of Stretchable, Dual Channel, Microfluidic Organ Chips

Published on: October 20, 2018

用器官芯片逆向工程人类病理生理学

Donald E Ingber¹

¹Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA 02115, USA; Vascular Biology Program, Departments of Pathology & Surgery, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA; Harvard John A. Paulson School of Engineering and Applied Sciences, Cambridge, MA 02138, USA.

|March 12, 2016

概括

此摘要是机器生成的。

人体器官芯片为研究细胞间通信和组织相互作用提供了一个新的实验系统. 这项技术为理解传统细胞培养之外的人类病理生理提供了更相关的器官背景.

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Combining Human Organoids and Organ-on-a-Chip Technology to Model Intestinal Region-Specific Functionality

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Published on: May 5, 2022

Construction of a Human Aorta Smooth Muscle Cell Organ-On-A-Chip Model for Recapitulating Biomechanical Strain in the Aortic Wall

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相关实验视频

Last Updated: May 1, 2026

Scalable Fabrication of Stretchable, Dual Channel, Microfluidic Organ Chips

Scalable Fabrication of Stretchable, Dual Channel, Microfluidic Organ Chips

Published on: October 20, 2018

Combining Human Organoids and Organ-on-a-Chip Technology to Model Intestinal Region-Specific Functionality

Combining Human Organoids and Organ-on-a-Chip Technology to Model Intestinal Region-Specific Functionality

Published on: May 5, 2022

Construction of a Human Aorta Smooth Muscle Cell Organ-On-A-Chip Model for Recapitulating Biomechanical Strain in the Aortic Wall

Construction of a Human Aorta Smooth Muscle Cell Organ-On-A-Chip Model for Recapitulating Biomechanical Strain in the Aortic Wall

Published on: July 6, 2022

科学领域:

生物医学工程
细胞生物学
病理生理学

背景情况:

培养细胞研究提供了对生物控制机制的洞察力.
了解人类病理生理学需要更相关的实验系统.
细胞间通信和组织间相互作用对于器官功能至关重要.

研究的目的:

引入人体器官芯片作为一种强大的新实验方法.
解决当前系统在研究复杂器官相互作用方面的局限性.
为了更深入地了解人类的病理生理学.

主要方法:

人体器官芯片模型的开发.
在器官环境中的细胞间通信分析.
使用微流体装置研究组织与组织的相互作用.

主要成果:

人体器官在芯片上可以在相关器官环境中进行分析.
这项技术有助于研究细胞间和组织间的相互作用.
与传统细胞培养相比,提供了更具生理相关性的模型.

结论:

人类器官在芯片上代表着实验生物学的重大进步.
这种方法有望解开人类病理生理学的复杂机制.
提供了更准确的疾病模型和药物开发的途径.