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Updated: Mar 24, 2026

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卡斯托尔蛋白是mTORC1通路的素传感器

Lynne Chantranupong1, Sonia M Scaria1, Robert A Saxton1

  • 1Department of Biology, Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology, 9 Cambridge Center, Cambridge, MA 02142, USA; Department of Biology, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Koch Institute for Integrative Cancer Research, 77 Massachusetts Avenue, Cambridge, MA 02139, USA; Broad Institute of Harvard and Massachusetts Institute of Technology, 415 Main Street, Cambridge MA 02142, USA.

Cell
|March 15, 2016
PubMed
概括

它与GATOR2相互作用,调节mTORC1路径. 这一发现阐明了氨酸缺乏如何抑制细胞生长信号.

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