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Real Time Detection of In Vitro Tumor Cell Apoptosis Induced by CD8+ T Cells to Study Immune Suppressive Functions of Tumor-infiltrating Myeloid Cells
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通过调节胆固醇代谢来增强CD8 ((+) T细胞的抗瘤反应

Wei Yang1, Yibing Bai1, Ying Xiong2

  • 1State Key Laboratory of Molecular Biology, National Center for Protein Science Shanghai, Shanghai Science Research Center, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China.

Nature
|March 17, 2016
PubMed
概括

抑制CD8 ((+) T细胞中的胆固醇化增强了它们的抗癌活性. 通过使用ACAT1抑制的方法, 通过促进T细胞对抗瘤的功能, 显示出癌症免疫疗法的前景.

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