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前列腺素E2通过先天性淋巴细胞IL-22轴抑制全身炎症

Rodger Duffin1, Richard A O'Connor1, Siobhan Crittenden1

  • 1Medical Research Council (MRC) Centre for Inflammation Research, Queen's Medical Research Institute, The University of Edinburgh, Edinburgh EH16 4TJ, UK.

Science (New York, N.Y.)
|March 19, 2016
PubMed
概括

通过EP4受体传递前列腺素E2 (PGE2) 信号对于控制全身炎症至关重要. 这种途径通过促进先天性淋巴细胞 (ILC) 产生介质素-22 (IL-22) 来支持肠道屏障的完整性.

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