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Kv3.3通道绑定Hax-1和Arp2/3组装一个稳定的局部Actin网络,调节通道门

Yalan Zhang1, Xiao-Feng Zhang2, Matthew R Fleming1

  • 1Department of Pharmacology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520.

Cell
|March 22, 2016
PubMed
概括

Kv3. 3通道通过 Hax-1 调节行为细胞骨的动态,这对于防止快速通道失活和神经元健康至关重要. 破坏这种相互作用的突变会导致神经退行.

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