中心突起的演变:来自弗雷明汉心脏研究的见解
Francesca N Delling1, Jian Rong2, Martin G Larson2
1From Boston University and National Heart, Lung & Blood Institute's Framingham Heart Study, Framingham, MA (F.N.D., J.R., B.L., E.O., P.S., E.J.B., R.S.V.); Department of Medicine (Cardiovascular Division), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA (F.N.D., D.F., B.H.); Neurology Section in the Department of Medicine, Boston University School of Medicine, MA (J.R.); Department of Mathematics and Statistics, Boston University, MA (M.G.L.); Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA (W.J.M.); Cardiology (E.J.B., R.S.V.) and Preventive Medicine Sections (E.J.B., R.S.V.), Department of Medicine, Boston University School of Medicine, MA; Department of Epidemiology, Boston University School of Public Health, MA (E.J.B., R.S.V.); and Cardiac Ultrasound Laboratory, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston (R.A.L.). fdelling@bidmc.harvard.edu.
非透性门脱落 (MVP) 形态可以发展为MVP. 在3至16年间,MVP可能会导致四分之一的患者出现显著的腹,说明书的变化表明进展.
科学领域:
- 心脏病学
- 心声检查
- 心脏膜疾病
背景情况:
- 在一般人群中,对关 (MVP) 进展的纵向研究很少.
- 这包括非诊断性MVP形态 (NDM) 的个体.
研究的目的:
- 调查MVP和NDM的纵向进展情况.
- 分析随着时间的推移中形态和功能的变化.
主要方法:
- 261名Framingham后代参与者在基线和3至16年后接受成像检查.
- 测量包括环形直径,叶片位移,厚度,合高度和吐喷射高度.
- 参与者被分为MVP,NDM (最小缩位移或异常前部吸收) 和健康参考人群.
主要成果:
- 与参考人群相比,MVP个体的传单位移,厚度和喷气高度增加.
- 17% 的 MVP 患者出现中度/ 严重的腹; 8% 患者进行了门修复.
- 80% 的异常前部合NDM进展为后部MVP.
- 34%的最小缩位移的NDM被重新归类为MVP或异常的前部吸收.
结论:
- 非二元的MVP形态可以演变为明显的MVP.
- 在3至16岁的患者中,大约有25%的患者出现MVP进展为显著的吐.
- 与NDM和MVP的进展有关.
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