来自Crenomytilus grayanus的多价值海洋莱克通过识别Gb3具有抗癌活性
Jiahn-Haur Liao1, Chih-Ta Henry Chien1,2, Han-Ying Wu3,4
1Institute of Biological Chemistry, Academia Sinica , Taipei 11529, Taiwan.
Journal of the American Chemical Society
|March 25, 2016
概括
在结构和功能上对一种海学菌,Crenomytilus grayanus lectin (CGL) 进行了表征. 这种莱克与乳腺癌细胞上的环球糖 (Gb3) 结合,这表明在癌症诊断和治疗中具有潜在的应用.
科学领域:
- 生物化学
- 结构生物学
- 海洋生物学
背景情况:
- 莱克是一种能结合碳水化合物的蛋白质.
- 海洋软体具有独特的讲解蛋白,
- Crenomytilus grayanus lectin (CGL) 是一种来自海洋软体的新型乳素.
研究的目的:
- 为了确定C. grayanus lectin (CGL) 的晶体结构
- 阐明CGL的碳水化合物结合特性和机制.
- 研究CGL在癌症治疗中的潜力.
主要方法:
- 进行X射线结晶学以了解决CGL结构.
- 分析CGL-连接物复合物 (银糖,银胺,环糖Gb3).
- 核磁共振 (NMR) 定位用于结合亲和力.
- 对乳腺癌细胞进行细胞活力测试.
主要成果:
- CGL表现出β三叶折叠,二元化成一个子形状.
- CGL具有三个不同的碳水化合物结合点,具有独特的亲和力.
- 在乳腺癌细胞上,CGL与全球糖 (Gb3) 结合,诱导细胞死亡.
结论:
- CGL具有独特的结构和多部位的碳水化合物结合能力.
- 在癌细胞上,CGL显示出Gb3的特异性识别.
- 对于癌症诊断和治疗策略的发展,
更多相关视频
09:03Establishment of Hepatocarcinoma in BALB/c-nu Mice and Investigation of the Therapeutic Effect of the Sanleng Jiashen Formula
Published on: January 26, 2024
778
10:18Author Spotlight: Exploring Seaweed's Bioactive Compounds for Sustainable Innovations in Industries
Published on: November 21, 2023
3.7K
相关概念视频
Targeted Cancer Therapies
9.1K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
9.1K
Selectins
4.7K
Cell adhesion is an essential aspect of multicellularity. While stable cell interactions usually occur between cells of the same type, transient cell interactions occur between cells of different tissue types, such as between neutrophils and endothelial cells. Selectins are one class of cell adhesion molecules (CAMs) that bind carbohydrate ligands to form transient cell adhesion. They are rod-like proteins with a long extracellular part of variable length ending with the lectin domain,...
4.7K
