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美国寨卡病毒:早期流行病学和遗传学发现

Nuno Rodrigues Faria^1,2, Raimunda do Socorro da Silva Azevedo³, Moritz U G Kraemer²

¹Center for Technological Innovation, Evandro Chagas Institute, Ministry of Health, Ananindeua, PA, 67030-000, Brazil.

Science (New York, N.Y.)

|March 26, 2016

概括

寨卡病毒 (ZIKV) 可能在2013年进入美洲,在巴西发现之前. 巴西ZIKV基因组的基因分析为了解其传播和演变提供了基础.

科学领域:

病毒学
流行病学
基因组学

背景情况:

巴西从2015年开始面临严重的寨卡病毒 (ZIKV) 流行.
寨卡病毒感染可能与同年晚些时候发现的小头病例有关.

研究的目的:

将巴西的ZIKV分离物进行基因特征.
确定ZIKV在美洲的引入和早期演变.

主要方法:

下一代测序七个巴西ZIKV基因组.
遗传学和分子时钟分析.
报告中ZIKV发病率与小头症之间的相关性分析.

主要成果:

遗传学分析显示,在2013年5月至12月期间,ZIKV只在美洲引入一次.
巴西ZIKV菌株与其他南美和加勒比海分离物有遗传联系.
在小头症患者的ZIKV基因组中没有发现常见的氨基酸变化.

结论:

这项研究为巴西和美洲的ZIKV建立了基因基线.
这些发现支持ZIKV在美洲的引入,早于其已知的出现.
需要进一步研究以了解ZIKV的分子流行病学和与先天性缺陷的联系.

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