在甲和乙的C-H化中以催化剂控制的选择性
Amanda K Cook1, Sydonie D Schimler1, Adam J Matzger1
1Department of Chemistry, University of Michigan, 930 North University Avenue, Ann Arbor, MI 48109, USA.
Science (New York, N.Y.)
|March 26, 2016
概括
研究人员开发了一种新的甲功能化方法. 过渡金属催化剂可以选择性C-H玻利化甲,克服其固有的惰性.
科学领域:
- 有机金属化学
- 催化剂
- 合成化学
背景情况:
- 甲的C-H键表现出显著的动力惰性,对选择性功能化提出了挑战.
- 开发高效的甲转化催化系统是化学的一个关键领域.
研究的目的:
- 报告一种新的过渡金属催化C-H甲.
- 研究甲功能化的催化剂依赖性选择性.
- 评估对比竞争基质的选择性,如环和乙.
主要方法:
- 使用,和复合物作为催化剂.
- 作为源使用 bis-pinacolborane (B2pin2).
- 在高甲压力 (28003500 kPa) 和温度 (150°C) 下在环素溶剂中进行反应.
主要成果:
- 通过使用多种过渡金属催化剂,成功实现了甲的C-H化.
- 催化剂的选择允许调整单体与二氧化甲产品的比率,而偏好CH3Bpin.
- 观察到甲比环和乙具有较高的选择性 (> 3.5:1).
结论:
- 过渡金属催化为选择性甲C-H化提供了有效的途径.
- 开发的方法提供可调节的选择性和高效率,克服甲的惰性.
- 这项工作推进了简单碳化合物的催化策略.
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