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Updated: Mar 23, 2026

Generation of Discriminative Human Monoclonal Antibodies from Rare Antigen-specific B Cells Circulating in Blood
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Published on: February 6, 2018

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艾滋病毒-1广泛中和抗体前体B细胞由生殖基因向免疫基因揭示

Joseph G Jardine1, Daniel W Kulp1, Colin Havenar-Daughton2

  • 1Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA. IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA. Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, CA 92037, USA.

Science (New York, N.Y.)
|March 26, 2016
PubMed
概括

研究人员开发了一种针对生殖基因的新型免疫原 (eOD-GT8),以启动广泛中和抗体 (bnAbs) 产生有效的艾滋病毒疫苗. 这种免疫原成功地识别和分离了人类的前体B细胞,支持其作为疫苗候选者的潜力.

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Retroviral Overexpression of CXCR4 on Murine B-1a Cells and Adoptive Transfer for Targeted B-1a Cell Migration to the Bone Marrow and IgM Production08:22

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The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
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