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Updated: Mar 23, 2026

Studying the Hypothalamic Insulin Signal to Peripheral Glucose Intolerance with a Continuous Drug Infusion System into the Mouse Brain
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Published on: January 4, 2018

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AgRP神经元通过棕色脂肪组织表达控制全身胰岛素敏感性

Sophie M Steculorum1, Johan Ruud1, Ismene Karakasilioti1

  • 1Department of Neuronal Control of Metabolism, Max Planck Institute for Metabolism Research, Gleueler Strasse 50, 50931 Cologne, Germany; Center for Endocrinology, Diabetes and Preventive Medicine (CEDP), University Hospital Cologne, Kerpener Strasse 26, 50924 Cologne, Germany; Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases (CECAD) and Center for Molecular Medicine Cologne (CMMC), University of Cologne, Joseph-Stelzmann-Strasse 26, 50931 Cologne, Germany.

Cell
|March 26, 2016
PubMed
概括

通过重新编程棕色脂肪,激活Agouti相关 (AgRP) 神经元驱动食和胰岛素抵抗. 向肌增强了胰岛素敏感性,显示出饥饿与血糖控制之间的联系.

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