调节基因的层次结构控制了C. elegans的幼虫到成人的发育切换
1Department of Cellular and Developmental Biology, Harvard University, Cambridge, Massachusetts 02138.
Cell
|April 7, 1989
概括
异常基因lin-4,lin-14,lin-28和lin-29在C. elegans发育过程中协调幼虫到成人的切换. 涉及这些基因的调节层次确保了在第四次 molt 期间皮下细胞命运变化的精确时间.
科学领域:
- 发育生物学 发展生物学
- 遗传学 是一个遗传学.
- 分子生物学分子生物学
背景情况:
- 异常基因控制了Caenorhabditis elegans的发育时间.
- 胚胎后发育涉及特定基因调节的特定阶段的事件.
研究的目的:
- 为了研究异常基因lin-4,lin-14,lin-28和lin-29的相互作用.
- 为了阐明C. elegans下皮细胞系中的幼虫到成年 (L/A) 切换的遗传控制.
主要方法:
- 对多种突变菌株的分析.
- 在发育过程中低皮细胞系的表型特征.
主要成果:
- 为L/A开关提出了一个监管层次模型.
- 在早期阶段,lin-14和lin-28会抑制lin-29.
- lin-4通过抑制lin-14和lin-28促进L/A切换,从而允许lin-29的激活.
结论:
- 这种L/A开关是由特定阶段的基因层次控制的.
- lin-29的激活会在第四次 molt 时引发关键的发育变化.
- lin-29很可能调节控制细胞分裂,分化和基因表达的下游基因.
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