心血管社区在精准医学倡议中的机遇
Svati H Shah1, Donna Arnett2, Steven R Houser2
1From Division of Cardiology, Department of Medicine, Duke University, Durham, NC (S.H.S., G.S.G.); Duke Molecular Physiology Institute, Duke University, Durham, NC (S.H.S.); School of Public Health, University of Alabama at Birmingham, Birmingham, AL (D.A.); Division of Cardiology, Department of Medicine, Temple University School of Medicine, Philadelphia, PA (S.R.H.); Cardiovascular Research Center, Temple University School of Medicine, Philadelphia, PA (S.R.H.); Duke Center for Personalized Medicine, Department of Medicine, Duke University, Durham, NC (G.S.G.); Division of Cardiology, Department of Medicine, Brigham and Women's Hospital, Boston, MA (C.M., J.L.); Division of Cardiology, Department of Pediatrics, The Hospital for Sick Children, Toronto, Canada (S.M.); and Lillehei Heart Institute, Division of Cardiology, Department of Medicine, University of Minnesota, Minneapolis, MN (J.L.H.). jlhall@umn.edu svati.shah@duke.edu.
精准医疗倡议旨在整合多样化的患者数据以提供个性化医疗服务. 这一框架探讨了心血管社区在这一倡议中的作用和挑战.
科学领域:
- 基因组学和生物信息学
- 心血管医学
- 翻译科学
背景情况:
- 精准医疗倡议 (PMI) 旨在通过整合全面的个人数据来加速个性化医疗保健.
- 目前PMI的重点是癌症基因组学,目标是扩展到所有健康领域,得到100万人的队列研究的支持.
- 心血管社区有很大的机会与PMI合作, 推进患者护理.
研究的目的:
- 为心血管社区参与精准医学倡议制定框架.
- 确定在心血管健康领域实施精准医学的主要挑战和机遇.
- 促进心血管科学家,临床医生和患者的意识和参与.
主要方法:
- 审查精准医学倡议的目标和结构.
- 分析数据整合要求,包括基因组学,生物标志物,生活方式,环境因素,可穿戴数据和电子健康记录.
- 确定心血管研究和临床界的潜在作用和贡献.
主要成果:
- PMI为心血管领域提供了一个独特的机会,为大规模数据整合做出贡献并从中受益.
- 成功实施需要解决数据标准化,可访问性和道德方面的挑战.
- 协作方法对于将精准医学原则转化为心血管临床实践至关重要.
结论:
- 心血管社区必须积极参与精准医学倡议,
- 克服实施挑战对于实现心血管健康准确医学的全部潜力至关重要.
- 积极参与将确保在PMI的更广泛范围内解决心血管需求.
相关概念视频
Blood Studies for Cardiovascular System I: Cardiac Biomarkers
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
Pharmacogenomics: Identification of New Drug Targets
Coronary Artery Disease IV: Preventive Measures
Combination Therapies and Personalized Medicine
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Combination Therapies and Personalized Medicine
Cardiomyopathy V: Interprofessional Care


