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Updated: May 6, 2026

Correlative Light and Electron Microscopy to Study Microglial Interactions with β-Amyloid Plaques
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在阿尔茨海默症小鼠模型中补充和微质介导早期突触损失

Soyon Hong1, Victoria F Beja-Glasser1, Bianca M Nfonoyim1

  • 1F.M. Kirby Neurobiology Center, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.

Science (New York, N.Y.)
|April 2, 2016
PubMed
概括

在阿尔茨海默病 (AD) 中,补充蛋白和微质会导致早期的突触损失. 抑制这些通路会减少突触损伤和微质活动,这表明AD是一种新的治疗点.

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Alzheimer disease involves structural changes in the brain that begin long before symptoms appear. The most distinctive features are extracellular neuritic plaques and intracellular neurofibrillary tangles.Neuritic plaques form in the cerebral cortex and around blood vessels. These plaques contain a dense core of beta-amyloid (Aβ)—a toxic protein fragment that clumps outside neurons. The core is surrounded by damaged neuronal extensions, as well as reactive astrocytes and...
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