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个性化免疫监测揭示了狼患者分层的分子网络

Romain Banchereau¹, Seunghee Hong¹, Brandi Cantarel¹

¹Baylor Institute for Immunology Research, Dallas, TX 75204, USA.

|April 5, 2016

概括

系统性红斑狼 (SLE) 呈现分子异质性,与血细胞和中性粒细胞特征相关,与疾病活性和炎相关. 个性化免疫监测有助于患者分层进行量身定制的治疗.

科学领域:

免疫学
遗传学
分子生物学

背景情况:

系统性红斑狼 (SLE) 是一种具有不同临床表现的自身免疫性疾病.
对核酸的耐受性丧失是SLE的一个关键特征.
了解分子异质性对于有效治疗SLE至关重要.

研究的目的:

通过纵向血液转录组分析,评估儿科患者SLE的分子异质性.
确定疾病活动和炎的强有力的生物标志物.
探索个性化免疫监测以进行患者分层和量身定制治疗.

主要方法:

对158名儿科SLE患者进行长度血液转录组分析.
对人口统计,治疗,疾病活动和炎的混合效应模型.
分析IFN,血细胞和中性粒细胞的特征.
基于基因型的个性化免疫监测和患者分层.

主要成果:

一个普遍的干扰素 (IFN) 签名被证实.
血细胞的特征是最可靠的疾病活动生物标志物.
中性粒细胞转录丰富与积极炎的进展相关.
在不同类型的炎中观察到不同的分子反应.
个性化免疫监测使患者分为七组.

结论:

SLE表现出显著的分子异质性,解释了临床试验的失败.
血细胞和中性粒细胞的特征是疾病活动和进展的关键指标.
个性化免疫监测和基因型支持分层提供了针对性SLE治疗的途径.
这种方法可以改善复杂自身免疫性疾病的临床试验设计.

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