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Updated: Mar 23, 2026

Defining Hsp33's Redox-regulated Chaperone Activity and Mapping Conformational Changes on Hsp33 Using Hydrogen-deuterium Exchange Mass Spectrometry
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降解性碳化支持在固独立生长期间的氧化还原稳定

Lei Jiang1, Alexander A Shestov2, Pamela Swain3

  • 1Children's Medical Center Research Institute, UT Southwestern Medical Center, Dallas, Texas 75390-8502, USA.

Nature
|April 7, 2016
PubMed
概括

癌细胞通过改变新陈代谢而适应在没有细胞粘附的情况下生长. 这项研究揭示了一种新的途径,其中细胞系异酸脱酶-1 (IDH1) 有助于控制反应性氧物种 (ROS) 并支持固独立癌细胞的瘤生长.

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