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核心生理时钟基因调节AML中的白血病干细胞

Rishi V Puram1, Monika S Kowalczyk2, Carl G de Boer2

  • 1Department of Medicine, Division of Hematology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; Program in Biological and Biomedical Sciences, Harvard Medical School, Boston, MA 02115, USA; Broad Institute of Harvard University and MIT, Cambridge, MA 02142, USA.

Cell
|April 9, 2016
PubMed
概括

核心生物钟基因Clock和Bmal1对于急性髓性白血病 (AML) 细胞生长至关重要. 破坏这些基因会阻止白血病的进展,并消耗白血病干细胞 (LSC).

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