在运动规划期间,前运动皮层中强大的神经动力学
Nuo Li1, Kayvon Daie1, Karel Svoboda1
1Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, Virginia 20147, USA.
Nature
|April 14, 2016
概括
神经表现是事件的桥梁, 但积极的反会导致不稳定. 鼠标前运动皮层的神经活动在单方面静止后强烈地恢复运动计划,突出显示半球间补偿.
科学领域:
- 神经科学
- 系统神经科学
- 发动机控制
背景情况:
- 神经活动维持过去和未来事件的表现.
- 有正反的网络模型可以表现出缓慢的动态,但对干扰很敏感.
研究的目的:
- 在运动规划过程中研究老鼠前运动皮层中持续的神经表现的稳定性.
- 了解神经网络如何从影响准备活动的干扰中恢复.
主要方法:
- 在小鼠前运动皮层中使用了电生理学和光遗传学扰动.
- 对前运动皮层进行单边和双边沉默.
- 体的切割被用来评估半球间的通信.
主要成果:
- 在单方面沉默后,驱动特定运动的预备神经活动迅速而有选择地恢复.
- 在双边沉默后,准备活动的选择性没有恢复.
- 运动前皮质半球表现出独立的准备性活动.
结论:
- 鼠标前运动皮质在运动规划过程中表现出显著的神经表现力,半球间补偿发挥着关键作用.
- 在前运动皮层的选择性合模块中的冗余性有助于强大的神经控制.
- 结合这些原则的网络模型可以解释神经动态的观察到的强度.
相关概念视频
Motor and Sensory Areas of the Cortex
8.9K
The cerebral cortex, the brain's outermost layer, is pivotal in processing complex cognitive tasks, emotions, and various sensory inputs and executing voluntary motor activities. This intricate structure is divided into three primary functional areas: the motor areas, sensory areas, and association areas.
Motor Areas
The motor areas located in the frontal lobe are central to controlling voluntary movements. This region is further subdivided into the primary motor cortex and the premotor cortex....
Motor Areas
The motor areas located in the frontal lobe are central to controlling voluntary movements. This region is further subdivided into the primary motor cortex and the premotor cortex....
8.9K
Direct Motor Pathways
5.1K
The direct motor pathways, also known as the pyramidal tracts, are a group of neural pathways that originate in the brain and descend through the spinal cord. They control the voluntary movement of the body. There are two major direct motor pathways: the corticospinal and the corticobulbar tracts.
The corticospinal tract is responsible for the voluntary movement of the limbs and trunk. It originates in the cerebral cortex of the brain and descends through the cerebrum's internal capsule and...
The corticospinal tract is responsible for the voluntary movement of the limbs and trunk. It originates in the cerebral cortex of the brain and descends through the cerebrum's internal capsule and...
5.1K
Hierarchy of Motor Control
6.7K
The hierarchy of motor control refers to the different levels of organization and processing involved in controlling movement in the body. These levels range from higher cortical areas involved in planning and decision-making to lower spinal cord reflexes that respond automatically to external stimuli.
6.7K
Propagation of Action Potentials
13.3K
The propagation of an action potential refers to the process by which a nerve impulse, or "action potential," travels along a neuron.
Neurons (nerve cells) have a resting membrane potential, with a slightly negative charge inside compared to outside. This is maintained by ion channels, such as sodium (Na+) and potassium (K+) channels, which control the flow of ions. When a stimulus, like a touch or a signal from another neuron, triggers the neuron, sodium channels open, allowing sodium ions to...
Neurons (nerve cells) have a resting membrane potential, with a slightly negative charge inside compared to outside. This is maintained by ion channels, such as sodium (Na+) and potassium (K+) channels, which control the flow of ions. When a stimulus, like a touch or a signal from another neuron, triggers the neuron, sodium channels open, allowing sodium ions to...
13.3K


