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Updated: Mar 22, 2026

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一个小分子RAS模拟器破坏了RAS与效应蛋白的关联,以阻止信号传输

Sai Krishna Athuluri-Divakar1, Rodrigo Vasquez-Del Carpio1, Kaushik Dutta2

  • 1Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY 10029, USA; Department of Structural and Chemical Biology, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY 10029, USA.

Cell
|April 23, 2016
PubMed
概括

通过阻断与RAS结合域 (RBDs) 的相互作用来抑制癌症驱动的RAS信号传递. 这种干扰影响了RAS-RAF-MEK等关键途径,

关键词:
美国其他国家英国空军一个RASRAS 绑定领域其他药物

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