甲状腺炎
Nicola Dalbeth1, Tony R Merriman2, Lisa K Stamp3
1Department of Medicine, University of Auckland, Auckland, New Zealand.
Lancet (London, England)
|April 27, 2016
概括
有效的痛风治疗需要将血清尿酸水平降至360μmol/L以下. 尽管有可用的治疗方法,如尿醇,但低率的尿酸降低治疗阻碍了发作抑制.
科学领域:
- 关节病学
- 结晶引起的关节炎
- 免疫学
背景情况:
- 痛风是一种慢性疾病,由单酸盐水晶沉积引起的血清酸盐升高.
- 遗传和环境因素会影响高尿血,脏和肠道尿酸分泌是关键的调节机制.
- 在引发急性痛风时,NLRP3炎症酶的激活和互白素-1β的释放至关重要.
研究的目的:
- 强调有效治疗痛风的"治疗到尿酸"策略的重要性.
- 为了突出长期血清酸盐降低到<60μmol/L的目标,以消除晶体溶解和燃烧.
- 确定需要改善痛风护理质量的战略.
主要方法:
- 审查当前对痛风病理生理学的理解,包括结晶形成和炎症途径.
- 讨论治疗方法,包括皮醇剂量升级和较新的尿酸降低药物.
- 全球尿酸降低疗法开始和持续率的分析.
主要成果:
- 达到血清尿酸的目标 (<360μmol/ L) 对于痛风治疗至关重要,导致晶体溶解和炎症抑制.
- 艾洛普醇剂量升级通常是有效的,并且有新的尿酸降低药物可用.
- 在全球范围内,尿酸降低治疗的开始和坚持是不理想的,导致治疗目标的实现很少.
结论:
- 治疗血清尿酸的方法对于有效治疗痛风至关重要.
- 目前低水平的尿酸降低疗法阻碍了全球成功的痛风治疗.
- 需要加强策略来提高痛风护理的质量和患者对治疗的坚持.
更多相关视频
相关概念视频
Gallbladder
2.8K
The gallbladder is a small, pear-shaped organ that plays a crucial role in our digestive system. Measuring about 10 cm in length, it is comparable in size to a kiwi fruit and is located in a hollow area on the lower surface of the liver. The gallbladder's primary function is to store and concentrate bile, a fluid produced by the liver that aids in digestion.
The gallbladder's anatomy consists of three regions: the fundus, body, and neck. Extending from the neck, the cystic duct joins...
The gallbladder's anatomy consists of three regions: the fundus, body, and neck. Extending from the neck, the cystic duct joins...
2.8K
Gastritis-I: Introduction and Types
3.2K
Gastritis, defined by the inflammation or irritation of the stomach lining or gastric mucosa, manifests in several distinct forms: acute, chronic, reactive, and a specific subtype known as autoimmune metaplastic atrophic gastritis.
Acute gastritis presents as a sudden inflammation triggered by various stressors to the stomach lining, such as exposure to corrosive agents, local irritants like aspirin and other NSAIDs, alcohol consumption, radiation therapy, physical trauma, severe burns, sepsis,...
Acute gastritis presents as a sudden inflammation triggered by various stressors to the stomach lining, such as exposure to corrosive agents, local irritants like aspirin and other NSAIDs, alcohol consumption, radiation therapy, physical trauma, severe burns, sepsis,...
3.2K
Genome-wide Association Studies-GWAS
16.5K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...
16.5K
Gastritis-II: Pathophysiology
1.7K
Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
1.7K
Gastritis III: Clinical Manifestations and Management
1.6K
The clinical manifestations of gastritis can vary depending on the cause and type of gastritis, but some common symptoms may include the following.
Clinical manifestations of acute gastritis
The patient with acute gastritis may have a rapid onset of symptoms, such as epigastric pain or discomfort, dyspepsia, anorexia, hiccups, or nausea and vomiting, which can last from a few hours to a few days. Erosive or hemorrhagic gastritis may cause bleeding, which may manifest as blood in vomit or as...
Clinical manifestations of acute gastritis
The patient with acute gastritis may have a rapid onset of symptoms, such as epigastric pain or discomfort, dyspepsia, anorexia, hiccups, or nausea and vomiting, which can last from a few hours to a few days. Erosive or hemorrhagic gastritis may cause bleeding, which may manifest as blood in vomit or as...
1.6K
Adrenal Gland Disorders
3.8K
Adrenal gland disorders manifest when the production of adrenal hormones deviates from the norm, resulting in either excessive or insufficient concentrations.
Adrenal insufficiency, characterized by insufficient cortisol and aldosterone production, leads to conditions like Addison's disease. This disorder, affecting the adrenal cortex, exhibits symptoms such as skin bronzing, dehydration, low blood pressure, fatigue, and weight loss. Congenital adrenal hyperplasia, a genetic ailment causing...
Adrenal insufficiency, characterized by insufficient cortisol and aldosterone production, leads to conditions like Addison's disease. This disorder, affecting the adrenal cortex, exhibits symptoms such as skin bronzing, dehydration, low blood pressure, fatigue, and weight loss. Congenital adrenal hyperplasia, a genetic ailment causing...
3.8K

![Quantitative SERS Detection of Uric Acid via Formation of Precise Plasmonic Nanojunctions within Aggregates of Gold Nanoparticles and Cucurbit[n]uril](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F61682.jpg&w=3840&q=50)
