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Updated: Mar 22, 2026

A Novel In Vitro Live-imaging Assay of Astrocyte-mediated Phagocytosis Using pH Indicator-conjugated Synaptosomes
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进激素缺乏通过补充激活促进微细胞对特定电路的突触修剪

Hansen Lui1, Jiasheng Zhang1, Stefanie R Makinson2

  • 1Department of Pathology, University of California, San Francisco, San Francisco, CA 94143, USA.

Cell
|April 27, 2016
PubMed
概括

在老鼠中,前列腺素缺乏导致年龄相关的微质激活,导致突触损失和强迫性行为. 抑制补充C1qa可以减轻这些神经退行性影响.

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In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
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