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Updated: Mar 22, 2026

Identification of Cyclin-dependent Kinase 1 Specific Phosphorylation Sites by an In Vitro Kinase Assay
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通过线粒化激活APC/C的分子机制

Suyang Zhang1, Leifu Chang1, Claudio Alfieri1

  • 1MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge, CB2 0QH, UK.

Nature
|April 28, 2016
PubMed
概括

通过蛋白质降解控制细胞分裂. 通过循环素依赖性激酶对APC/ C的酸化起到切换作用,使Cdc20激活并调节线粒分裂. 这项研究揭示了这一关键过程的分子机制.

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