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在活跃的生物系统中,在中观尺度上破碎的详细平衡

Christopher Battle¹, Chase P Broedersz², Nikta Fakhri³

¹Drittes Physikalisches Institut, Georg-August-Universität, 37077 Göttingen, Germany. The Kavli Institute for Theoretical Physics, University of California, Santa Barbara, CA 93106, USA.

Science (New York, N.Y.)

|April 30, 2016

概括

生物系统在热力学平衡之外运行, 违反了详细的平衡. 这项研究引入了一种检测细胞动态中破坏的详细平衡的方法,揭示了不平衡过程.

科学领域:

生物物理
细胞生物学
热力学

背景情况:

热力学平衡中的系统表现出时间独立的特性,并满足详细的平衡.
生物系统本质上是不平衡的, 有定向的分子流动违反了详细的平衡.

研究的目的:

引入一种探测破碎细节平衡的方法.
为了证明不平衡的动态如何表现在中视尺度上.
为识别生物系统中的不平衡动态提供一个通用工具.

主要方法:

对鞭子击中形状的相空间的概率流量分析.
在静止,不平衡的随机系统中量化破碎的详细平衡模型的开发.
实验观察初级眼的细节平衡的波动.

主要成果:

周期性的鞭子跳动显示了概率流动, 表明细节平衡被破坏.
在没有周期运动的静止不平衡系统中,可以量化破碎的详细平衡.
上皮细胞的初级乳毛的非周期性波动显示出细节平衡的破坏.

结论:

这项研究提出了一种用于识别生物系统不平衡动态的新方法.
破碎的详细平衡是细胞功能的可测量特征.
这种方法提供了分析细胞和组织动态的一般工具.

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