补充NAD+可以改善线粒体和干细胞的功能,并增加小鼠的寿命
Hongbo Zhang1, Dongryeol Ryu1, Yibo Wu2
1Laboratory of Integrative and Systems Physiology, École Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland.
Science (New York, N.Y.)
|April 30, 2016
概括
尼古丁胺核糖酸 (NR) 通过增加线粒体活动和NAD () 水平,使衰老的肌肉干细胞 (MuSCs) 复苏. 这种方法延迟了各种干细胞的衰老,并延长了小鼠的寿命.
科学领域:
- 细胞衰老
- 线粒体功能
- 干细胞生物学
背景情况:
- 成人干细胞对于组织修复至关重要,但随着年龄的增长而下降.
- 细胞衰老 (衰老) 损害了 SC 功能.
- 氧化尼古丁胺氨基二核酸 (NAD ((+)) 水平影响线粒体活动和SC健康.
研究的目的:
- 研究NAD在调节肌肉干细胞 (MuSC) 衰老中的作用.
- 确定NAD ((+) 前体是否可以使老化的MuSC复苏.
- 探讨改善寿命的NAD(+) 保护策略的潜力.
主要方法:
- 给老年小鼠使用尼古丁胺核糖酸 (NR),一种NAD的前体.
- 使用MDX小鼠模型治疗肌肉衰竭.
- 评估了MuSC功能,衰老标志物和线粒体活动.
- 对神经SCs,黑色细胞SCs和老鼠的整体寿命进行了评估.
主要成果:
- NR治疗诱导了线粒体未折叠的蛋白质反应和禁止素合成.
- 在老老的小鼠中,NR使MuSCs复发,在mdx小鼠中防止老化.
- 在神经和黑色细胞SC中NR延迟衰老.
- NR的使用延长了小鼠的寿命.
结论:
- NAD ((+) 水平和线粒体活动是SC衰老的关键调节剂.
- NR治疗有效地使老年和功能障碍的SC复苏.
- 保护细胞NAD的策略对抗衰老和延长寿命具有前景.
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