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Osmotic Minipump Implantation for Increasing Glucose Concentration in Mouse Cerebrospinal Fluid
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骨髓细胞衍生的VEGF维持大脑的葡萄糖吸收并限制肥胖症的认知障碍

Alexander Jais1, Maite Solas1, Heiko Backes2

  • 1Department of Neuronal Control of Metabolism, Max Planck Institute for Metabolism Research, Gleueler Strasse 50, 50931 Cologne, Germany; Center for Endocrinology, Diabetes and Preventive Medicine (CEDP), University Hospital Cologne, 50924 Cologne, Germany; Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases (CECAD) and Center of Molecular Medicine Cologne (CMMC), University of Cologne, Joseph Stelzmann Strasse 26, 50931 Cologne, Germany.

Cell
|May 3, 2016
PubMed
概括

高脂肪饮食最初通过降低大脑血管中的葡萄糖转运体-1 (GLUT-1) 来降低大脑的葡萄糖吸收. 巨细胞分泌的血管内皮生长因子 (VEGF) 后来恢复了这种吸收,防止肥胖的认知衰退.

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