在基底中对立和双向的运动速度控制
Eric A Yttri1, Joshua T Dudman1
1Janelia Research Campus, Howard Hughes Medical Institute, 19700 Helix Drive, Ashburn, Virginia 20147, USA.
Nature
|May 3, 2016
概括
基底腺
科学领域:
- 神经科学
- 发动机控制
- 行为可塑性
背景情况:
- 基底结结合了运动电路与目标导向行为的奖励信号.
- 脊椎条纹体的直接和间接途径参与了行动选择.
- 活动依赖性可塑性在改进运动动力学中的作用尚不清楚.
研究的目的:
- 调查基底的活动依赖性可塑性是否足以学习运动动力学的变化.
- 确定直接和间接路径是否可以双向控制运动速度.
主要方法:
- 在小鼠移动过程中以闭环方式进行细胞类型特定的刺激.
- 使用多巴胺抗剂来评估多巴胺在学习行为变化中的作用.
主要成果:
- 直接或间接路径中的活动足以诱导运动速度的特定持续变化.
- 这些速度变化代表了学习,在试验中积累,并在刺激停止后持续.
- 多巴胺抗剂消除了这些学习的行为修改.
结论:
- 基底的直接和间接路径可以双向控制运动速度.
- 这表明基底性质对运动动力学的特定和灵活的意志控制.
- 这些路径的活动依赖性可塑性是运动速度的学习调整的基础.
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