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通过线粒体未折叠蛋白反应维护和传播有害的线粒体基因组

Yi-Fan Lin1, Anna M Schulz1, Mark W Pellegrino1

  • 1Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.

Nature
|May 3, 2016
PubMed
概括

线粒体DNA (mtDNA) 缺失导致细胞功能障碍. 线粒体未折叠蛋白响应 (UPR) 激活ATFS-1,这令人惊地传播了这些有害的mtDNA删除.

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