心脏衰竭的胃肠和肝脏问题
Varun Sundaram1, James C Fang2
1From Harrington Heart and Vascular Institute, University Hospitals Case Medical Center, Cleveland, OH (V.S.); and Division of Cardiovascular Medicine, University of Utah Health Science Center, Salt Lake City (J.C.F.).
Circulation
|May 5, 2016
概括
心脏衰竭 (HF) 影响全球数以百万计的人,影响多个器官系统. 这篇综述详细介绍了胃肠道和肝脏参与HF的机制和后果.
科学领域:
- 心脏病学
- 胃肠病学
- 肝病学
背景情况:
- 尽管有先进的治疗方法, 但心脏衰竭 (HF) 影响着全世界数以百万计的人, 死亡率高.
- 这是一种复杂的综合征,影响内分泌,脏,肝脏和胃肠道系统.
- 胃肠道和肝脏的参与是常见的,增加了发病率和死亡率.
研究的目的:
- 审查胃肠道和肝脏系统在HF的参与.
- 阐明肠道和肝脏功能障碍与HF相关的病理生理机制.
- 描述胃肠道和肝脏干扰患者的临床后果.
主要方法:
- 对HF,胃肠道系统和肝脏系统的文献综述.
- 分析病理生理机制,包括细胞因子环境,荷尔蒙和代谢失衡.
- 与HF相关的肠道和肝脏问题的临床后果和结果的综合.
主要成果:
- 在HF患者中,胃肠道和肝脏系统受到显著影响.
- 这种机制包括炎症,荷尔蒙失调和代谢变化.
- 这些功能障碍有助于HF的进展和较差的结果.
结论:
- 肠肝轴在HF病理生理学中起着至关重要的作用.
- 了解这些机制对于开发有效的治疗策略至关重要.
- 需要进一步的研究来解决HF和肠肝功能障碍之间的双向关系.
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