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Updated: Mar 21, 2026

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基他胺代谢物的NMDAR抑制独立的抗抑郁作用

Panos Zanos1, Ruin Moaddel2, Patrick J Morris3

  • 1Department of Psychiatry, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA.

Nature
|May 5, 2016
PubMed
概括

胺的抗抑郁作用依赖于其代谢物氨基胺 (HNK). 通过AMPA受体激活,而不是NMDAR抑制, (2R,6R) -HNK反体表现出抗抑郁作用,并且缺乏胺.

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