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Improving Translational Accuracy02:07

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Base complementarity between the three base pairs of mRNA codon and the tRNA anticodon is not a failsafe mechanism. Inaccuracies can range from a single mismatch to no correct base pairing at all. The free energy difference between the correct and nearly correct base pairs can be as small as 3 kcal/ mol. With complementarity being the only proofreading step, the estimated error frequency would be one wrong amino acid in every 100 amino acids incorporated. However, error frequencies observed in...
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Lesson: Translation
Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
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Translation01:31

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Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
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Proteins are...
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在翻译中拯救失落的东西

Sinje Gehr1, Craig C Garner2

  • 1Charité - Universitätsmedizin Berlin, 10117 Berlin, Germany.

Cell
|May 7, 2016
PubMed
概括

将学术医学发明转化为公共卫生解决方案面临的挑战是由于学术界和行业的文化差距. 新举措促进创业和伙伴关系,加快新疗法的发展.

科学领域:

  • 生物医学创新
  • 技术转让
  • 公共卫生

背景情况:

  • 具有公共卫生潜力的学术发明往往面临翻译困难.
  • 学术界和工业界之间的文化差异阻碍了从实验室到市场的发现.
  • 这种差距可能会推迟或阻止重大公共卫生进展.

研究的目的:

  • 探索翻译学术医学发明的挑战.
  • 确定学术界和工业界之间的文化差异在这个过程中的作用.
  • 突出旨在加快治疗转换的新举措.

主要方法:

  • 对学术创业现有文献进行分析.
  • 审查医疗创新的公私伙伴关系的案例研究.
  • 审查政策变化和资金举措.

主要成果:

  • 学术研究和工业发展之间的文化和结构差异是重要的障碍.
  • 促进学术创业的新计划有望弥合这一差距.
  • 加强公私伙伴关系对于调整激励和专业知识至关重要.

结论:

  • 克服学术界和行业的文化差异是成功翻译医学发明的关键.

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  • 支持学术创业和公私合作的倡议加快了拯救生命的治疗方法的发展.
  • 这些努力对于科学发现对公众健康的影响至关重要.