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相关概念视频

Flow Cytometry01:23

Flow Cytometry

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The development of flow cytometry techniques began in 1934 with initial attempts by Andrew Moldavan, a bacteriologist who counted the cells in a flowing capillary system. Moldavan pumped cells through a capillary tube focused under a microscope for visualization. The invention of photometry allowed the measurement of differentially-stained cells, and Louis Kamentsky developed the first multiparameter flow cytometer in 1965 to identify and count the cancer cells in cervical tissue specimens.
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Mass Cytometry Analysis of Systemic and Local Immune Responses in Hepatocellular Carcinoma
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大量细胞计:单细胞,多种特征

Matthew H Spitzer1, Garry P Nolan2

  • 1Baxter Laboratory in Stem Cell Biology, Department of Microbiology and Immunology, Stanford University, Stanford, CA 94305, USA; Program in Immunology, Stanford University, Stanford, CA 94305, USA; Department of Pathology, Stanford University, Stanford, CA 94305, USA; Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94143, USA.

Cell
|May 7, 2016
PubMed
概括
此摘要是机器生成的。

质量细胞计将流量细胞计和质量谱相结合,以单细胞分辨率同时测量40多种细胞特征,从而提升生物研究能力.

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科学领域:

  • 生物研究技术
  • 单细胞分析
  • 细胞测量

背景情况:

  • 流细胞计能够测量单细胞中的多个细胞特征.
  • 传统的流量细胞计平衡具有特征数和分辨率.
  • 复杂的细胞系统需要先进的分析工具.

研究的目的:

  • 审查目前的质量细胞计量状态.
  • 提供质量细胞计仪器,能力和数据分析的概述.
  • 讨论量细胞计的未来发展和应用.

主要方法:

  • 通过流细胞测量来提高质谱的精度.
  • 大量细胞测量仪器的开发.
  • 质谱原理应用于细胞分析.

主要成果:

  • 质量细胞计可以同时测量40多个细胞参数.
  • 在复杂的生物样本中实现单细胞分辨率.
  • 显著增加复杂的细胞系统和过程的评估.

结论:

  • 大量细胞测量代表了细胞测量的重大进步.
  • 它增强了研究复杂细胞功能的能力.
  • 未来的发展有望在生物研究中得到更广泛的应用.