通过柱子显著促进水凝的胀[6]arene-Ferrocene复合与多刺激响应
Mengfei Ni1, Ning Zhang1, Wei Xia1
1Key Laboratory of Mesoscopic Chemistry of MOE, Collaborative Innovation Center of Chemistry for Life Sciences, School of Chemistry and Chemical Engineering, Nanjing University , Nanjing, 210023, China.
Journal of the American Chemical Society
|May 10, 2016
概括
这项研究提出了具有铁素组的智能水凝,在水溶性柱状溶液中显著膨胀. 这种新材料显示出对多种刺激的响应性和对pH响应的药物递送应用的潜力.
科学领域:
- 材料科学
- 聚合物化学
- 超分子化学
背景情况:
- 在执行器和药物输送等应用中, 水凝的膨胀和缩小至关重要.
- 智能水凝提供可调节的性能,
研究的目的:
- 制造一种新型的智能水凝,
- 在水溶性柱状 (WP6) 溶液中研究水凝的膨胀行为.
- 探索水凝对各种刺激的反应及其在药物输送中的潜力.
主要方法:
- 用悬挂铁基组功能化的聚合物网络水凝的制造
- 将水凝浸入水溶性柱体[6] (WP6) 的水溶液中.
- 评估水凝膨胀,多刺激反应 (温度,pH,氧化还原,竞争性客体) 和药物释放能力.
主要成果:
- 在WP6溶液中,由于WP6铁素含有复合物的形成,水凝的重量增加了大约11倍.
- 膨胀的水凝表现出对温度,pH,氧化还原条件和竞争性客人的反应.
- 智能水凝显示出对pH反应药物释放应用的潜力.
结论:
- 一种新型含铁素的水凝成功合成.
- 水凝的显著胀和多刺激反应归因于与WP6的超分子相互作用.
- 这种智能水凝可用于先进的应用,
相关概念视频
02:34Regioselectivity and Stereochemistry of Acid-Catalyzed Hydration
The rate of acid-catalyzed hydration of alkenes depends on the alkene's structure, as the presence of alkyl substituents at the double bond can significantly influence the rate.
01:17Thermal Electrocyclic Reactions: Stereochemistry
The stereochemistry of electrocyclic reactions is strongly influenced by the orbital symmetry of the polyene HOMO. Under thermal conditions, the reaction proceeds via the ground-state HOMO.
Selection Rules: Thermal Activation
Conjugated systems containing an even number of π-electron pairs undergo a conrotatory ring closure. For example, thermal electrocyclization of (2E,4E)-2,4-hexadiene, a conjugated diene containing two π-electron pairs, gives trans-3,4-dimethylcyclobutene.
Selection Rules: Thermal Activation
Conjugated systems containing an even number of π-electron pairs undergo a conrotatory ring closure. For example, thermal electrocyclization of (2E,4E)-2,4-hexadiene, a conjugated diene containing two π-electron pairs, gives trans-3,4-dimethylcyclobutene.
01:26Photochemical Electrocyclic Reactions: Stereochemistry
The absorption of UV–visible light by conjugated systems causes the promotion of an electron from the ground state to the excited state. Consequently, photochemical electrocyclic reactions proceed via the excited-state HOMO rather than the ground-state HOMO. Since the ground- and excited-state HOMOs have different symmetries, the stereochemical outcome of electrocyclic reactions depends on the mode of activation; i.e., thermal or photochemical.
Selection Rules: Photochemical Activation
Selection Rules: Photochemical Activation
![[4+2] Cycloaddition of Conjugated Dienes: Diels–Alder Reaction](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2Ffiles%2Fmedia%2Fscience-education%2Fscience-education-thumbs%2F12417.jpg&w=3840&q=75)
01:16[4+2] Cycloaddition of Conjugated Dienes: Diels–Alder Reaction
The Diels–Alder reaction is an example of a thermal pericyclic reaction between a conjugated diene and an alkene or alkyne, commonly referred to as a dienophile. The reaction involves a concerted movement of six π electrons, four from the diene and two from the dienophile, forming an unsaturated six-membered ring. As a result, these reactions are classified as [4+2] cycloadditions.
01:29Diels–Alder Reaction: Characteristics of Dienes
The Diels–Alder reaction brings together a diene and a dienophile to form a six-membered ring. Both components have unique characteristics that influence the rate of the reaction.
Characteristics of the diene
Conformation
The simplest example of a diene is 1,3-butadiene, an acyclic conjugated π system. At room temperature, the molecule exists as a mixture of s-cis and s-trans conformers by virtue of rotation around the carbon–carbon single bond. Although the s-trans isomer is more stable, the...
Characteristics of the diene
Conformation
The simplest example of a diene is 1,3-butadiene, an acyclic conjugated π system. At room temperature, the molecule exists as a mixture of s-cis and s-trans conformers by virtue of rotation around the carbon–carbon single bond. Although the s-trans isomer is more stable, the...
01:29Diels–Alder Reaction Forming Bridged Bicyclic Products: Stereochemistry
Diels–Alder reactions between cyclic dienes locked in an s-cis configuration and dienophiles yield bridged bicyclic products.