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基因组H3K36突变通过改变基因组甲基化场景促进了瘤发生

Chao Lu1, Siddhant U Jain2, Dominik Hoelper2

  • 1Laboratory of Chromatin Biology and Epigenetics, The Rockefeller University, New York, NY 10065, USA.

Science (New York, N.Y.)
|May 14, 2016
PubMed
概括

基因组H3突变 (H3K36M) 通过破坏甲基化模式,损害细胞分化并驱动肉瘤的形成. 这种机制在儿童癌症和人类不分化的瘤中被观察到.

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