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吞尸体会产生一种分子记忆,

Helen Weavers¹, Iwan R Evans², Paul Martin³

¹Department of Biochemistry, Biomedical Sciences, University of Bristol, Bristol BS8 1TD, UK; Department of Cellular and Molecular Medicine, Biomedical Sciences, University of Bristol, Bristol BS8 1TD, UK.

|May 24, 2016

概括

巨细胞可以通过吞细胞来发展记忆,从而增强它们对随后的损伤或感染的反应. 这种启动涉及诱导的JNK信号和德雷珀受体的上调.

科学领域:

免疫学
细胞生物学
德洛索菲拉黑虫研究

背景情况:

巨细胞是重要的先天免疫细胞, 在健康和疾病中发挥着不同的作用.
虽然适应性免疫因免疫记忆而闻名,但最近的发现表明,像巨细胞这样的先天免疫细胞也可能具有记忆能力.
之前的研究集中在感染后的巨细胞记忆,但其他刺激的记忆诱导仍然不太清楚.

研究的目的:

为了研究巨细胞是否能在感染以外的信号下产生记忆.
阐明巨细胞获得和利用这种记忆的机制.
确定死体吞在巨细胞炎症反应中的作用.

主要方法:

使用Drosophila melanogaster作为体内研究的模型生物.
研究了亡尸体对随后的炎症反应的影响.
分析了所涉及的信号通路,包括诱导的JNK信号.
检查了损伤受体在这个过程中的作用.

主要成果:

随着Drosophila巨细胞吞尸体,它们就会对随后的组织损伤和感染产生强烈的炎症反应.
这种启动是由诱导的JNK信号介导的.
这一过程导致损伤受体Draper的上调,建立了分子记忆.
这种记忆使人们对次要的侮辱做出更快,更有力的回应.

结论:

巨吞细胞诱导某种形式的分子记忆,增强先天的免疫反应.
-JNK-Draper通路对于这种记忆形成和功能至关重要.
这一发现突显了巨细胞的可塑性以及它们作为炎症疾病的治疗点的潜力.

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