全基因组关联研究确定了74个与教育成就相关的位置
Aysu Okbay1,2,3, Jonathan P Beauchamp4, Mark Alan Fontana5
1Department of Applied Economics, Erasmus School of Economics, Erasmus University Rotterdam, Rotterdam, 3062 PA, The Netherlands.
Nature
|May 27, 2016
概括
遗传因素影响教育成就,一项大规模的全基因组关联研究确定了74个重要位置. 这些遗传变异与胎儿大脑基因调节和神经发育途径有关.
科学领域:
- 行为遗传学
- 神经科学
- 基因组学
背景情况:
- 教育成就受到社会和环境因素的影响.
- 遗传因素对个人教育水平的差异有很大影响.
- 之前的研究已经发现了一些遗传关联,但需要更大的样本.
研究的目的:
- 使用大规模的全基因组关联研究 (GWAS) 识别与教育成就相关的遗传位置.
- 研究与已识别的遗传变异相关的生物途径和基因表达模式.
- 探索教育成就作为相关特征的代理表型的实用性.
主要方法:
- 对293723个人的扩大样本进行了全基因组关联研究 (GWAS).
- 在英国生物库的111,349名独立样本中进行了复制研究.
- 分析了单核酸多态 (SNP) 与学龄相关.
主要成果:
- 确定了74个与教育成就相关的全基因组显著位置.
- 发现相关SNP在调节胎儿大脑基因表达的基因组区域中被丰富.
- 候选基因在神经组织中优先表达,特别是在产前发育过程中,并且与神经发育途径相关.
结论:
- 一个强大的GWAS可以识别可复制的遗传变异以实现教育,这是一个复杂的行为表型.
- 遗传发现表明生物相关的途径,特别是那些参与神经发育的途径.
- 教育成就是研究对认知和神经精神疾病的遗传影响的有价值的代理表型.
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