英国胡蝶的工业黑色素变异是一种可转移的元素
Arjen E Van't Hof1, Pascal Campagne1, Daniel J Rigden1
1Institute of Integrative Biology, University of Liverpool, Biosciences Building, Crown Street, Liverpool L69 7ZB, UK.
Nature
|June 3, 2016
概括
导致蝶产业黑色素的突变是一种可转移的元素插入皮质基因. 这种插入,大约1819年,增加皮质基因表达,驱动适应污染.
科学领域:
- 进化生物学
- 遗传学
- 分子生物学
背景情况:
- 胡蝶 (Biston betularia) 的工业黑色素是适应的一个典型例子.
- 黑色素体 (碳素体) 的基因已被定位,但尚未确定.
- 了解推动这种可见进化反应的突变至关重要.
研究的目的:
- 找出导致蝶工业黑色素的特定突变.
- 阐明这种突变导致表型变化的分子机制.
- 为了确定突变事件的时间.
主要方法:
- 精确地绘制碳质的位置.
- 序列分析以确定遗传差异.
- 转化时间的统计推断.
- 对基因表达变化的分析.
主要成果:
- 这种突变是一个大型的,并联重复的可转移元素, 插入到皮层基因的第一个内核中.
- 统计分析表明转移发生在1819年左右.
- 可转移的元素增加了皮层转录的丰富性.
- 在翅膀发育过程中,皮质蛋白参与细胞循环调节.
结论:
- 这项发现确定了在胡蝶中驱动工业黑色素的特定突变.
- 可转移的元素可以成为主要的表型新性和快速适应的来源.
- 这一发现为一个标志性的进化事件提供了分子解释.
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