宿主-微生物群相互性中的合作微生物耐受性行为
1Nomis Center for Immunobiology and Microbial Pathogenesis, the Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
Cell
|June 4, 2016
概括
有益的微生物和病原体一样, 这种观点表明,这些行为促进了宿主健康和耐受性,促进了合作宿主微生物的进化.
科学领域:
- 微生物学
- 进化生物学
- 主体与微生物的相互作用
背景情况:
- 动物对微生物的防御传统上集中在免疫系统的抵抗机制上.
- 这种对抗性的观点使得理解有益的宿主-微生物关系变得复杂.
- 致病微生物表现出以牺牲宿主为代价的行为.
研究的目的:
- 为宿主-微生物相互作用提出一个补充框架.
- 这表明有益的微生物也进化了操纵宿主过程的行为.
- 探索这些行为如何促进宿主健康和微生物健康.
主要方法:
- 对宿主-微生物动态现有研究的概念分析和综合.
- 在致病和有益相互作用的背景下探索微生物行为.
- 宿主-微生物系统进化动态的理论建模.
主要成果:
- 有益的微生物采用类似于病原体的行为.
- 这些行为被认为是为了促进宿主耐受性和健康, 而不是伤害.
- 微生物行为的这种双重作用可以导致合作的进化动态.
结论:
- 有益的微生物可以操纵宿主过程,通过促进宿主健康来提高它们的健康.
- 传统上与病变相关的微生物行为也可以驱动宿主耐受性.
- 这种观点支持宿主和微生物之间的共同进化.
相关概念视频
Microbial Interactions: Cooperation
1
Microbial cooperation involves beneficial interactions in which different species work together for individual or mutual advantage. These interactions can profoundly influence ecological dynamics and evolutionary processes, and they are essential to many pathogenic and symbiotic relationships.Nematode–Bacteria CooperationA striking example is the relationship between the Gram-negative bacterium Xenorhabdus nematophila and the parasitic nematode Steinernema carpocapsae. Juvenile nematodes...
1
Microbial Interactions: Mutualism
1
Mutualism is a symbiotic interaction in which all participating organisms benefit. These relationships can be obligate or facultative and are fundamental to ecosystem functions across diverse biological systems.Plant–Fungi MutualismOne well-known example is the association between plant roots and mycorrhizal fungi, such as Rhizophagus species. The fungal hyphae penetrate the root hairs and the epidermis, forming an extensive hyphal network that establishes a symbiotic association. Through...
1
Microbial Interactions: Competition
6
Microbial competition is an ecological interaction in which microorganisms vie for limited resources within shared environments. These resources may include nutrients, space, or light, depending on the system. The intensity and outcome of competition are influenced by the environmental context, such as nutrient availability, spatial constraints, and the diversity of microbial species present. These competitive interactions significantly influence the structure, function, and resilience of...
6
Microbial Interactions: Parasitism
1
Parasitism is a form of microbial interaction in which parasitic microbes exploit a host organism for nutrients and shelter, often at the host's expense. Unlike mutualistic relationships, where both organisms benefit, parasitism benefits only the parasite and harms the host.Classification of ParasitesMicrobial parasites are broadly classified based on their location relative to the host.Ectoparasites remain on the host’s surface, such as the skin or outer tissues, drawing nutrients...
1
Microbe-Plant Interactions
6
Microbe-plant interactions represent a dynamic spectrum of associations shaped by intricate chemical signaling. These interactions can be neutral, beneficial, or detrimental, and profoundly influence plant physiology, growth, and ecosystem function. The plant microbiome, comprising bacteria, fungi, archaea, protists, and viruses, plays a pivotal role in mediating these effects through surface colonization, internal colonization, or systemic symbiosis.Mutualistic associations, particularly with...
6
Functions of the Gut Microbiota
1
The gut microbiota includes trillions of microorganisms that colonize the human gastrointestinal tract, including bacteria, archaea, viruses, and fungi. This complex ecosystem plays a critical role in maintaining intestinal and systemic health. Most of these microbes inhabit the large intestine, establishing a relatively stable and diverse community that contributes to gut homeostasis through various metabolic, immunological, and protective mechanisms.Dominant bacterial phyla, such as...
1


