银 - 乳纳米复合物作为一种强大的抗菌剂
Paweł Pomastowski1, Myroslav Sprynskyy1, Petar Žuvela2
1Department of Environmental Chemistry and Bioanalytics, Faculty of Chemistry, Interdisciplinary Centre for Modern Technologies, Nicolaus Copernicus University , 87-100 Toruń, Poland.
Journal of the American Chemical Society
|June 7, 2016
概括
银在牛乳酸 (LTF) 中的固定涉及两阶段的异质过程,导致具有针对临床细菌的抗菌活性的复合物.
科学领域:
- 生物材料科学
- 纳米技术
- 微生物学
背景情况:
- 牛乳 (LTF) 是一种有前途的药物输送生物材料.
- 银纳米颗粒具有强大的抗菌特性.
- 开发有效的白银-LTF复合物需要了解固定机制.
研究的目的:
- 调查LTF中的银体固定.
- 描述银-LTF复合物的物理化学特性.
- 评估Ag-LTF复合物的抗菌活性.
主要方法:
- 批量吸附动力学,MALDI-TOF/TOF-MS,ICP-MS,FTIR,SERS,TEM,I-DE,泽塔电位测量
- 分子动力学 (MD) 和密度函数理论 (DFT) 模拟.
- 流细胞测量和抗菌素测定用于抗菌评估.
主要成果:
- 银在LTF中的固定遵循一个异质的两阶段过程:外部吸附和内部扩散/结合.
- 光谱和显微分析证实了LTF结构中的银结合.
- 模拟阐明了结合机制,并支持了银离子的减少.
- 合成的Ag-LTF复合物对临床细菌具有显著的抗菌活性.
结论:
- 这项研究阐明了白银在LTF中的固定机制.
- Ag-LTF复合物具有经过验证的抗菌性质.
- 这项研究支持新型抗菌生物材料的开发.
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