在36个月前一次全身麻醉暴露与儿童后期神经认知结果之间的关联
Lena S Sun1, Guohua Li2, Tonya L K Miller3
1Morgan Stanley Children's Hospital-New York Presbyterian, Columbia University Medical Center, New York, New York.
JAMA
|June 9, 2016
概括
与兄弟姐妹相比,幼儿一次麻醉并没有影响其后的智商或行为. 对于重复或长时间的麻醉效果需要进一步的研究.
科学领域:
- 儿童麻醉学
- 神经发育儿科
- 儿童心理学
背景情况:
- 年轻动物的麻醉暴露与神经毒性有关.
- 了解儿童潜在的神经认知和行为影响至关重要.
研究的目的:
- 调查健康幼儿一次性麻醉是否与晚年儿童神经认知发育和行为受损相关.
主要方法:
- 参与105对8至15岁儿童的兄弟姐妹相匹配的队列研究.
- 一个兄弟在36个月前接受了全身麻醉; 另一个没有.
- 通过神经心理测试和家长报告评估神经认知功能 (IQ) 和行为.
主要成果:
- 在暴露和未暴露的兄弟姐妹之间没有观察到全尺度,表现或口头智商分数的统计学意义上的差异.
- 包括记忆,运动技能,注意力,执行功能,语言和行为在内的二次结果也没有显著差异.
结论:
- 在健康的儿童中,一次性全身麻醉在36个月前没有与智商或儿童后期行为的显著差异有关.
- 需要对重复或长时间麻醉暴露和易受伤害的人群的影响进行进一步的研究.
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