在挫败的易斯对框架中发生的-克莱森类型反应
Guo-Qiang Chen1, Gerald Kehr1, Christian Mück-Lichtenfeld1
1Organisch-Chemisches, Institut der Universität Münster , Corrensstraβe 40, 48149 Münster, Germany.
Journal of the American Chemical Society
|June 16, 2016
概括
丧的易斯对 (FLP) 促进与乙乙和的反应,产生新的异环中间体. 这些中间体被重新排列,形成替代的乙,其中单个案例显示环烯的形成或C-C键的激活.
科学领域:
- 有机化学
- 易斯对化学
- 有机合成
背景情况:
- 丧的易斯对 (FLP) 是由易斯酸和基形成的反应性物种,不形成经典的附加物.
- 不和/FLPs在催化各种有机转化方面表现有前途.
- 与非和碳化合物相结合的C4桥式/FLP的反应性仍然是一个需要探索的领域.
研究的目的:
- 研究C4桥式不和/FLPs与乙烯基和的反应.
- 阐明异环中间体的形成及其随后的重组产物.
- 探索潜在的异常反应路径和机械洞察力.
主要方法:
- /FLP与各种乙烯基和的反应
- 使用光谱方法对反应中间体和产品进行表征.
- 关键化合物的X射线衍射分析以确认结构.
主要成果:
- 含有酸/酸功能的10个分子异环中间体的形成.
- 随后的-克莱森类型重组产生替代.
- 观察了两个特殊情况,其中包括环环形成和碳-碳键激活.
结论:
- 在新型异环化合物的合成中,C4桥式不和/FLP是有效的.
- 这项研究揭示了通过-克莱森重组获得替代酸的多功能合成途径.
- 异常反应途径突显了FLP的复杂反应性,并为合成探索提供了新的途径.
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