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相关概念视频

Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

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Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
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相关实验视频

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Generation of hiPSC-Derived Intestinal Organoids for Developmental and Disease Modelling Applications
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Generation of hiPSC-Derived Intestinal Organoids for Developmental and Disease Modelling Applications

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使用器官模拟发展和疾病

Hans Clevers1

  • 1Hubrecht Institute/Royal Netherlands Academy of Arts and Sciences, Princess Maxima Centre and University Medical Centre Utrecht, 3584CT Utrecht, The Netherlands.

Cell
|June 18, 2016
PubMed
概括

器官技术利用3D干细胞培养来模仿人类器官的发育和疾病. 这些来自患者的器官具有个性化医疗,药物反应预测和基因治疗应用的潜力.

科学领域:

  • 生物医学工程
  • 发育生物学
  • 干细胞生物学

背景情况:

  • 最近3D培养技术的进步使哺乳动物干细胞能够自我组织.
  • 这些自我组织的干细胞培养,被称为器官,复制各种人体器官的结构和功能特征,包括脏,肺,肠道,大脑和视网膜.

研究的目的:

  • 突出器官技术在人类器官发育和疾病模型中的能力.
  • 讨论患者衍生器官对个性化药物反应预测的潜力.
  • 探索有机体在再生医学和基因治疗中的新兴应用.

主要方法:

  • 使用先进的3D培养技术.
  • 培养胚胎和成年哺乳动物干细胞.
  • 开发模仿特定人体器官的器官.

主要成果:

  • 有机体成功地反映了肝脏,肺,肠道,大脑和视网膜等器官的主要结构和功能.
  • 器官技术是人类器官发育和病理的体外建模的强大工具.
  • 在预测个体药物反应方面,患者衍生器官具有前景.

结论:

  • 机器人技术为研究人类发育和疾病提供了新的方法.

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  • 在个性化医疗和再生疗法方面,
  • 器官技术的全部潜力,包括与基因编辑的整合,仍在探索中.